Sensitization tests are conducted to determine the potential of a substance to cause skin sensitization. Learn more about Skin Sensitization Assay Kits here. 

Unlike instaCELL Phospholipidosis Assay Kits, these tests are important in identifying potentially harmful substances and ensuring the safety of products. Skin sensitization assay kits are available to conduct these tests. There are two types of skin sensitization assay kits available: in vitro and in vivo. In the later section of the blog, we discuss them in detail. 

Types Of Skin Sensitization Assay Kits

In vitro tests are conducted using cells and tissues in a laboratory setting. While people usually conduct in vivo tests on living animals.

In vitro sensitization assay kits are becoming more widespread. The reason is the ethical concerns regarding the use of animals in testing. These kits use human-derived cells and tissues to mimic the human immune response to a substance.

One popular in vitro sensitization assay kit is the Direct Peptide Reactivity Assay (DPRA). The DPRA uses synthetic peptides to predict the sensitization potential of a substance. The test is based on the ability of the substance to react with cysteine or lysine residues in peptides. This can indicate the potential for sensitization.

Another in vitro sensitization assay kit is the Human Cell Line Activation Test (h-CLAT). This kit uses human peripheral blood mononuclear cells to measure the activation of dendritic cells in response to a substance. This activation can indicate the potential for sensitization.

In vivo sensitization assay kits are still common in some cases. Particularly when required by regulatory agencies. The Local Lymph Node Assay (LLNA) is a common in vivo sensitization assay kit. This test involves exposing mice to a substance and measuring the activation of lymphocytes in the lymph nodes.

It is important to note that while sensitization tests are important in identifying potentially harmful substances, they are not foolproof. It is still possible for a substance to cause sensitization in humans despite testing negative in an assay kit. Therefore, it is important to conduct multiple tests and consider all available data when assessing the safety of a substance.

General Summary Of Sensitization Assay Tests

Sensitization tests for assay kits are important tools used to identify potentially harmful substances and ensure the safety of products. In vitro sensitization assay kits are becoming more widely used due to ethical concerns, but in vivo tests are still required in some cases. It is important to conduct multiple tests and consider all available data when assessing the safety of a substance.

Conclusion

Quality comes first, always! This is why we suggest you get in touch with us. We have remained the most dependable Thermo fisher distributors for several years. So the next time you want to purchase Keratinosens Assay Kit, you know whom to call!